Regardless of the problem, we'd like to help you find what you're looking for. I've been taking Plaquenil 400 mg for nearly 6 mos. Plaquenil for spondyloarthritis Plaquenil use in patients Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. This medicine may cause muscle and nerve problems. Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. Plaquenil and muscle weakness Plaquenil weakness - Road Back Foundation, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine cancer clinical trials Can Plaquenil cause Muscle Weakness? Muscle Weakness is a known side effect of Plaquenil. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Can Plaquenil cause Muscle Weakness? - Treato. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Plaquenil and muscle weakness Lupus Forums at The Lupus Site. Muscle weakness also may be a side effect of certain drugs used to treat lupus and related conditions, including prednisone and other corticosteroids, cholesterol-lowering drugs and hydroxychloroquine Plaquenil®. Therefore, drug-induced muscle disease should be ruled out as a cause of weakness if you are taking any of these medications, as drug-induced muscle weakness usually does not produce elevated levels of muscle enzymes as is seen in lupus myositis. Dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. This can happen in individuals with a condition known as G6PD deficiency or porphyria. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more Muscular weakness is found among people who take Fluconazole and Plaquenil, especially for people who are female, 60+ old, have been taking the drugs for 6 - 12 months, also take medication Lisinopril, and have Antibiotic therapy. This review analyzes which people have Muscular weakness with Fluconazole and Plaquenil.