Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Can i take tramadol with plaquenil Plaquenil and retinal damage Curvilinear bodies hydroxychloroquine cardiomyopathy Plaquenil maculopathy visual field Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Lupus-Specific Skin Disease and Skin Problems Most people with lupus experience some sort of skin involvement during the course of their disease. In fact, skin conditions comprise 4 of the 11 criteria used by the American College of Rheumatology for classifying lupus. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil discolor yiur skin Skin Color Change -, Lupus-Specific Skin Disease and Skin Problems Johns. Plaquenil treatment for sclerodermaPlaquenil cause disufl In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. I have have been on plaquenil for over a year. It's really made my RA manageable, however, Plaquenil is an anti-malarial and pretty well known for its possible skin discoloration side effects. As you can guess from the title, I now have a beautiful melasma mustache and melasma across my cheeks and forehead. It's great. I've been on Plaquenil 400mg a day for almost 4 years. I haven't noticed any skin discoloration but my hair turned grey at a very young age and I've always kept it natural, but as of late it is turning yellowish and my hair dresser thinks it is from the medication. Was this page helpful? Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. In general, the re-try approach that has been used, plaquenil and skin discoloration several different nexium drip dose, is 2.