While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I was on this hydroxychloroquine for 6 months and then suddenly developed severe itching (burning like sensation, worse than any itch I have ever had) and rash that went from my neck to my feet. Plaquenil for osteoarthritis Chloroquine for malaria infection Mylan hydroxychloroquine side effects Yes, plaquenil should help with all or most lupus symptoms, fatigue, pain, rashes, etc. Here is a link to my blog about lupus meds. Dec 05, 2017 Importantly, it tends to be very effective for a number of generalized symptoms such as joint pain and fatigue, and may help somewhat to control progression. As others have stated, it can take awhile to kick in, and as long as six months to reach full effect. Plaquenil and Fatigue - a study from real-world data. Summary Fatigue is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. Plaquenil (hydroxychloroquine) is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Plaquenil helps fatigue Sjögrens Fatigue – an Autoimmune Conundrum! SjögrensLife, Experiences taking Plaquenil for Fatigue and Muscle Pain. Plaquenil 200 mg daily Plaquenil has been a life-saving drug for me, quite literally. I was a mess in 2004-2005 and then a dr put me on Plaquenil, and in 3 weeks most of my symptoms had disappeared. Hydroxychloroquine Reviews Everyday Health. Will you have Fatigue with Plaquenil - eHealthMe. PLAQUENIL To Take or Not To Take?" Lupus Community.. Is extreme fatigue a side effect of Plaquenil - NRAS. Is extreme fatigue a side effect of Plaquenil. I've been on Plaquenil now for three months and its starting to help with the pain although I have diarrhoea every day but it's manageable. But I'm really struggling with fatigue now - worse than its ever been. Plaquenil does relieve much of the fatigue. As for the joint pain, still a problem. Yes, depression is an issue, still is. The form of meditation I practice is called Mindfulness Based Stress Reduction and daily practicing helps relieve the symptoms of depression. Apr 17, 2014 I completely agree with Lynnwood that plaquenil helps stop the progression of your disease, so the longer you wait the worse your Sjogren's becomes. Plaquenil is a fairly benign medication and was originally developed to protect against malaria. Later it was found to help autoimmune diseases. It can be months before you get relief with plaquenil.