Chloroquine endosome

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  1. soser New Member

    Chloroquine endosome

    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    To examine the effect of chloroquine treatment on endocytic pathway compartments, we performed Western blotting of lysates of the cells, which had been treated with 1 μM chloroquine for 5 days, using antibodies specific to Rab5, Rab7 and Rab4, which are proteins specifically associated with early endosomes, late endosomes and recycling vesicles, respectively. Chloroquine is known to be a non-specific antiviral agent, but its effect on the Zika virus replication has not been evaluated yet. This is the first report of inhibitory effects of chloroquine on ZIKV replication, which, given the ongoing epidemics, may become interesting both for the scientific knowledge of the virus and for the clinical. To examine the consequences of UPS buffering of luminal pH on endosome protein coat maturation, UPS 6.2 and UPS 4.4 were selected to study the recruitment of the Rab5 GTPase, which is a discriminating feature of early endosome pH 6.0–6.5 biogenesis, and LAMP2, which is a biomarker of lysosomes pH 4.0–4.5. Fluorescent dextran was used.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine endosome

    Targeting endosomal acidification by chloroquine analogs as a promising., Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus.

  2. Chloroquine powder
  3. Chemical treatment of cells with an endosomal trafficking inhibitor that blocks endosome progression, bafilomycin A1, resulted in a significant decrease in eTE. However, treatment of cells with lysosomotropic agents chloroquine and ammonium chloride had little effects on eTE.

    • Distinct effects of endosomal escape and inhibition of..
    • Investigation of endosome and lysosome biology by ultra pH..
    • Chloroquine Dosage Guide with Precautions -.

    Mar 11, 2002 Chloroquine is one of the drugs commonly used to treat malaria in parts of sub-Saharan Africa, where HIV infection is endemic 3, 27, 31, 47. Our initial observation that chloroquine increased the infectivity of HIV suggested that administration of chloroquine to HIV-infected patients could potentially exacerbate the course of HIV infection. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Jan 23, 2017 Inhibitors of endosome acidification such as chloroquine block the viral permeabilization event in endosome Stuart and Brown 2006. Treatment with chloroquine significantly reduces the replication of caliciviruses including porcine enteric calicivirus, murine norovirus‐1 and feline calicivirus in vitro Shivanna et al. 2014.

  4. Demitri New Member

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  5. BoyStav Moderator

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