The clinical trials on this list are studying Hydroxychloroquine. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. Plaquenil for weight loss Hydroxychloroquine and the flu Hydroxychloroquine 200mg equivalent to methotrexate Hydroxychloroquine immunosuppressant Non–small-cell lung cancer NSCLC is the most common cause of cancer mortality in the United States 1 and chemotherapy is only modestly effective. Studies in genetically engineered mouse models demonstrate that autophagy inhibition suppresses lung tumor development and progression, especially in Kras mutated tumors. We report safety and efficacy of adding an autophagy inhibitor, hydroxychloroquine HCQ to front-line platinum-based chemotherapy in a phase Ib single arm study in patients with metastatic NSCLC. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Talk to your doctor for help in deciding if one is right for you. You may want to think about taking part in a clinical trial. Hydroxychloroquine and lung cancer Repurposing Drugs in Oncology ReDO—chloroquine and., Modulation of autophagy with hydroxychloroquine in patients. Chloroquine interfere nucleic acid biosynthesis One of the treatments for small cell lung cancer SCLC is chemotherapy. The chemotherapy most often used is a carboplatin and etoposide. This is a standard treatment. Recent research shows that a drug called hydroxychloroquine HCQ might help chemotherapy work better. A trial of chemotherapy and hydroxychloroquine for small.. Chloroquine and hydroxychloroquine for cancer therapy. Hydroxychloroquine + Carboplatin, Paclitaxel and Bevacizumab in Non.. Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine and Gefitinib to Treat Lung Cancer. Non-small cell lung cancer NSCLC is the most common cause of cancer mortality in men and women in Singapore. Chemotherapy and biologically targeted agents can extend survival only modestly for these patients; therefore, discovery of novel ways to prolong the disease course is a top research.