Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Revised recommendations on screening for chloroquine and hydroxychloroquine Monitoring hydroxychloroquine Both groups experienced increase of insulin level, but this change was considerably higher in those groups receiving hydroxychloroquine. The group receiving hydroxychloroquine experienced reduction of glucose at 60 min of Oral Glucose Tolerance Test OGTT test after intervention, while the placebo group experienced increase of blood glucose at the same time. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine increase metroxtrate Plaquenil Hydroxychloroquine - Side Effects, Dosage., Rheumatoid Arthritis Treatment Options Johns Hopkins. Doxycycline and plaquenil interactionsHow longbto take plaquenil after alcoholPlaquenil and pepto bismolPlaquenil and sore eyesPlaquenil dilated pupils Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Plaquenil hydroxychloroquine sulfate dose, indications.. Methotrexate vs Plaquenil Comparison -. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease. Taking methotrexate with hydroxychloroquine has not been studied. It may increase your risk of side effects. Taking cyclosporine with hydroxychloroquine can increase the amount of cyclosporine in. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks.