It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine cardiomyopathy beyond ocular adverse effects Alternativesto taking plaquenil Your doctor may diagnose morphea by examining the affected skin and asking you about your signs and symptoms. He or she may take a small sample of the affected skin skin biopsy for examination in the laboratory. This may reveal changes in your skin, such as thickening of a protein collagen in the second layer of skin dermis. Feb 19, 2020 Skin and subcutaneous tissue disorders Rash, pruritus, pigmentation disorders in skin and mucous membranes, hair color changes, alopecia. Dermatitis bullous eruptions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms DRESS syndrome. Aug 18, 2011 Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Skin changes with plaquenil Plaquenil Hydroxychloroquine - Side Effects, Dosage., Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Side effects of plaquenil and methotrexateCan plaquenil cause restless leg syndromeP falciparum resistance to chloroquine Dec 25, 2011 Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps Plaquenil and spots on skin DailyStrength. Skin Discoloration and Plaquenil - Arthritis Information. Common and Rare Side Effects for Plaquenil Oral. Apr 10, 2019 Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Before using Plaquenil, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism, or glucose-6. As lichen planus heals, it often leaves dark brown spots on the skin. Like the bumps, these spots may fade without treatment. If they do not go away, dermatologists can lighten the spots with creams, lasers, or other treatments. Lichen planus in the mouth often lasts longer than lichen planus on the skin. In the mouth, it can be harder to treat. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear.