The main finding in scleroderma is thickening and tightening of the skin and inflammation and scarring of many body parts, leading to problems in the lungs, kidneys, heart, intestinal system and other areas. Twins and family members of those with scleroderma or other autoimmune connective tissue diseases, such as lupus, may have a slightly higher risk of getting scleroderma. There is still no cure for scleroderma, but effective treatments for some forms of the disease are available. Children can also develop scleroderma, but the disease is different in children than in adults. Common ingredients of chloroquine Act with chloroquine tafenoquine Mar 17, 2019 Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. The cause isn’t known, but CREST syndrome limited scleroderma is believed to be an autoimmune disorder, in which your immune system turns against your body. The immune system in people with CREST syndrome appears to stimulate cells called fibroblasts to produce excess amounts of collagen, a key component of connective tissue. Because no two cases of Scleroderma are alike, identifying your disease subtype, stage, and involved organs is very important in determining the best course of action for treatment. Current therapies use medications that focus on the four main features of the disease inflammation, autoimmunity, vascular disease, and tissue fibrosis. A great deal of research is also underway to find better treatments for scleroderma and, hopefully, someday a cure. Although the underlying cause is unknown, promising research is shedding light on the relationship between the immune system and scleroderma. Hydroxychloroquine for crest syndrome CREST syndrome Genetic and Rare Diseases Information Center GARD., CREST syndrome causes, signs, symptoms, diagnosis & treatment Plaquenil ulcerative colitisHydroxychloroquine sul 200Plaquenil common side effectsMichael marmor plaquenil dec 2015 Nov 25, 2019 Detailed Hydroxychloroquine dosage information for adults and children. Includes dosages for Rheumatoid Arthritis, Systemic Lupus Erythematosus, Malaria Prophylaxis and more; plus renal, liver and dialysis adjustments. Hydroxychloroquine Dosage Guide with Precautions -. Scleroderma Treatment Options Johns Hopkins Scleroderma Center. Scleroderma Treatment General – Standard - Scleroderma Education Project. For months now my skin has been thickening I have now reached the point where I feel as though my arms are going to split like a sausage and been extremely inflamed and painful. A month ago I started on Plaquenil and prednisolone. It has helped a bit with the inflammation but on reading various. Alpert MA, Pressly TA, Mukerji V, et al. Acute and long-term effects of nifedipine on pulmonary and systemic hemodynamics in patients with pulmonary hypertension associated with diffuse systemic sclerosis, the CREST syndrome and mixed connective tissue disease. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments.