Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine copay assistance Side effect plaquenil nausea Applies to hydroxychloroquine compounding powder, oral tablet. Cardiovascular. Frequency not reported Cardiomyopathy can result in fatal cardiac failure, biventricular hypertrophy. Dermatologic-Pigmentary changes in skin and mucous membranes, bleaching of hair, and alopecia are usually reversible when therapy is discontinued. Plaquenil hydroxychloroquine 200mg is it causing itchy skin rash? My lupus flares are Skin manifestation only malar rashplus fatigue. But ESR n CRP keeps coming Normal including ANA. On plaquenil hydroxychloroquine. Was dx not correct? I am on Metrotexate 30 mg a week, 2 Plaquenil hydroxychloroquine a day, 5 mg Prednisone. I got this after about 5 weeks, mine was a blistery rash and it was only on my shoulders, upper chest and upper back. My doctor said it was photodermatitis and caused from a sensitivity to the sun caused by the plaquenil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil skin rash Plaqunil rash -, I had a skin rash from plaquenil hydroxychloroquine. I. Plaquenil retinal screening interval Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Rash from plaquenil DailyStrength. Hydroxychloroquine Skin Support. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. I wonder if the commencement of the skin rashes and itching is related in some way to this decreased effectiveness of the medication too. So far from the other posts it may seems that Plaquenil may be somehow associated with skin rash that looks like small hives and patchy itchiness. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.