Chloroquine exocytosis

Discussion in 'Canadian Pharcharmy Online' started by kav, 08-Mar-2020.

  1. Pixel_2K XenForo Moderator

    Chloroquine exocytosis


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Treatment with the weak base chloroquine, which helps phagosome neutralization, significantly decreased the rate of nonlytic exocytosis. Since ammonium chloride, another weak base, plays an insignificant role in nonlytic exocytosis, we hypothesized that chloroquine may regulate nonlytic exocytosis via a phagosome-independent pathway. Chloroquine is known to be a non-specific antiviral agent, but its effect on the Zika virus replication has not been evaluated yet. This is the first report of inhibitory effects of chloroquine on ZIKV replication, which, given the ongoing epidemics, may become interesting both for the scientific knowledge of the virus and for the clinical. Variations of endocytic and of lysosomal functions during the cell cycle have been investigated in synchronized hepatoma cells derived from Morris hepatoma 7288c by following the cellular uptake of horseradish peroxidase, dextran mol wt. 70,000, and chloroquine.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine exocytosis

    Chloroquine Indications, Side Effects, Warnings -, Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika.

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  6. We also discuss the importance of understanding the mesoscopic regulation of exocytosis and its molecular mechanism, and then propose future avenues of research in this field, emphasizing the need to study the role of the cortical actin network on different levels over the full range of regulated exocytosis, which is inherently a 3D process.

    • Actin Remodeling in Regulated Exocytosis Toward a..
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    Dec 22, 2006 To examine the effect of chloroquine treatment on endocytic pathway compartments, we performed Western blotting of lysates of the cells, which had been treated with 1 μM chloroquine for 5 days, using antibodies specific to Rab5, Rab7 and Rab4, which are proteins specifically associated with early endosomes, late endosomes and recycling vesicles, respectively. THE JOURNAL OF BIOLOGICAL CHEMISTRY 63 1986 hy The American Society of Biological Chemists, Inc. Vol. 261, No. 9, Issue of March 25, pp. 39463951,1986 Printed in USA. Insulin Stimulates Fluid-phase Endocytosis and Exocytosis in 3T3-Ll Adipocytes* Received for publication, July 15,1985 Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

     
  7. evg700 User

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine and Hydroxychloroquine Toxicity Practice Essentials. Chloroquine vs Hydroxychloroquine Comparison - Hydroxychloroquine Uses, Dosage & Side Effects -
     
  8. Proger-bobber XenForo Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine Professional Patient Advice - Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Uses, Dosage & Side Effects -
     
  9. alex_black New Member

    Eye screening for patients taking hydroxychloroquine Plaquenil Macular Society Eye screening for patients taking hydroxychloroquine. Hydroxychloroquine is a medication used to treat several conditions including rheumatoid arthritis, systemic lupus erythematosus, some skin conditions especially photosensitive ones and others that involve inflammation.

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