Effect of chloroquine on liver enzymes

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  1. sibil New Member

    Effect of chloroquine on liver enzymes

    Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. We observed statistically significant generation of reactive oxygen species, liver toxicity, and oxidative stress. Our observation of alterations in biochemical parameters was strongly supported by real-time PCR measurement of m RNA expression of key biochemical enzymes involved in hepatic toxicity and oxidative stress.

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    The depressed activity of microsomal NADPH cytochrome c reductase was ameliorated by chloroquine. These results indicate that enzyme activities change independently of a change in phospholipid content in the subcellular organelles during ischemia. 6 The three enzyme activities remained depressed in the liver of the non-treated rat 24 h. Effects of chloroquine and Nifedipine on the phospholipid content and enzyme activity in the subcellular fraction of ischemic rat liver. Kayawake S, Narbaitz R, Kako KJ. Ask your doctor about what chloroquine dose to take to treat rheumatoid arthritis, lupus, or sarcoidosis. Chloroquine Overdose. Symptoms of a chloroquine overdose may include Drowsiness; Dizziness

    We further tested quercetin, an antioxidant flavanoid, against CQ-induced hepatoxicity and found encouraging results as quercetin was able to drastically reduce the oxidative stress and hepatotoxicity resulting at higher dosages of CQ administration. However, the observed hepatotoxicity and accompanying oxidative stress following CQ administration show dose specific pattern with little or apparently no effect at therapeutic dose while having severe effects at higher dosages.

    Effect of chloroquine on liver enzymes

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Effects of chloroquine and Nifedipine on the phospholipid.

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  4. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

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    In the case of 100 mg kg −1 day −1 the effect was highly significant compared with the other doses 10 and 30 mg kg −1 day −1. The results of the study revealed that α‐lipoic acid could offer protection against chloroquine‐induced hepatotoxicity. α‐Lipoic acid had a better protective effect when compared with silymarin, a. Aug 14, 2017 Rheumatoid arthritis is an autoimmune disease that is treated with a variety of medications, including non-steroidal anti-inflammatory drugs, or NSAIDs, and disease modifying anti-rheumatic drugs, or DMARDs. Many of these medications can cause elevated liver enzymes and liver complications. Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal.

  5. RomanPR Guest

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil vs. Aralen Prescription Treatment for Malaria. Effects of chronic exposure of hydroxychloroquine. Risks of Hydroxychloroquine
  6. yolka XenForo Moderator

    Hydroxychloroquine Plaquenil - Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone.

    Hydroxychloroquine Side-effects, uses, time to work