To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Can i take plaquenil with percocet Chloroquine cyclosporin Plaquenil nursing considerations SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucer” sign, and peripapillary nerve fiber layer thinning 12–14. Few reports have examined progression of changes in SD-OCT appearance after drug cessation. Of 2361 patients who had taken hydroxychloroquine continuously for at least 5 years and who had 10-2 visual fields or SD-OCT, 177 7.5% showed clear signs of retinal toxicity. None of the primary medical indications for hydroxychloroquine therapy were significantly associated with an increased prevalence of retinal toxicity. The “Flying saucer” sign. Figure 2a and 2b this classic representation of Plaquenil toxicity is a preservation of the outer retinal layers subfoveally with perifoveal loss of the IS/OS junction on both sides of the fovea. Perifoveal IS/OS junction loss is associated with perifoveal outer retinal thinning, resulting in an ovoid appearance in the central retina, creating the flying saucer sign. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Flying saucer sign plaquenil Multimodal Imaging in Plaquenil Toxicity, Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA Plaquenil tab 200 mg caj c 20Does methotrexate work without plaquenil Plaquenil “Flying Saucer Sign” Disruption to the ellipsoid zone line/parafoveal thinning Disruption to the ellipsoid zone EZ line Chen E, et al. Clinical Ophthalmology 2010. Optic nerve evaluation Optical Coherence Tomography Too good to be true?. How to Succeed in Plaquenil Screenings. UFO Club Beerknurd - Flying Saucer Draught Emporium. Screening should be aimed at detection of the earliest functional and anatomic changes, even before a “flying saucer” sign is evident on SD-OCT. Such changes include subtle field loss, the first stages of mfERG abnormality, beginning disruption of the inner segment–outer segment lines or cone outer segment tip lines, and documentation of. Figure 5 The flying saucer sign of Chen, et al. 2 Take Home Points Early detection of hydroxychloroquine Plaquenil related retinopathy is critical to preventing irreversible vision loss. Dec 04, 2014 Spectral-domain optical coherence tomography Bilateral parafoveal outer retinal and retinal pigment epithelium atrophy with central sparing “flying saucer sign” Recently, there has been some focus on the effects of HCQ on the inner retinal layers.