Flying saucer sign plaquenil

Discussion in 'Canadian Pharcharmy Online' started by Fable, 11-Mar-2020.

  1. whynot New Member

    Flying saucer sign plaquenil


    To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation.

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    SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucersign, and peripapillary nerve fiber layer thinning 12–14. Few reports have examined progression of changes in SD-OCT appearance after drug cessation. Of 2361 patients who had taken hydroxychloroquine continuously for at least 5 years and who had 10-2 visual fields or SD-OCT, 177 7.5% showed clear signs of retinal toxicity. None of the primary medical indications for hydroxychloroquine therapy were significantly associated with an increased prevalence of retinal toxicity. The “Flying saucersign. Figure 2a and 2b this classic representation of Plaquenil toxicity is a preservation of the outer retinal layers subfoveally with perifoveal loss of the IS/OS junction on both sides of the fovea. Perifoveal IS/OS junction loss is associated with perifoveal outer retinal thinning, resulting in an ovoid appearance in the central retina, creating the flying saucer sign.

    Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center.

    Flying saucer sign plaquenil

    Multimodal Imaging in Plaquenil Toxicity, Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA

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  4. PlaquenilFlying Saucer Sign” Disruption to the ellipsoid zone line/parafoveal thinning Disruption to the ellipsoid zone EZ line Chen E, et al. Clinical Ophthalmology 2010. Optic nerve evaluation

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    Screening should be aimed at detection of the earliest functional and anatomic changes, even before a “flying saucersign is evident on SD-OCT. Such changes include subtle field loss, the first stages of mfERG abnormality, beginning disruption of the inner segment–outer segment lines or cone outer segment tip lines, and documentation of. Figure 5 The flying saucer sign of Chen, et al. 2 Take Home Points Early detection of hydroxychloroquine Plaquenil related retinopathy is critical to preventing irreversible vision loss. Dec 04, 2014 Spectral-domain optical coherence tomography Bilateral parafoveal outer retinal and retinal pigment epithelium atrophy with central sparing “flying saucer sign” Recently, there has been some focus on the effects of HCQ on the inner retinal layers.

     
  5. ak471985 User

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. AAO Screening Guidelines for Plaquenil My Take on New Ocular Screening Guidelines for Plaquenil. Preferred Practice Pattern® Guidelines - American Academy of.
     
  6. Ataman Moderator

    Chloroquine Pharmacology & Usage Details Medicine India Chloroquine About Chloroquine 4- Aminoquinoline, excellent schizonticide, Antimalarial, amebicide, anti inflammatory and local irritant. Mechanism of Action of Chloroquine Malarial parasites digest their own haemoglobin and release highly toxic heme.

    Chloroquine Ligand page IUPHAR/BPS Guide to PHARMACOLOGY
     
  7. Nika New Member

    Hydroxychloroquine Sulfate - Posts about Drugs, Side effects. Learn about Hydroxychloroquine Sulfate from patients' first hand experiences and trusted online health resources, including dosage, side effects and interactions. 202 discussions on Treato

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