Those with APS make abnormal proteins called antiphospholipid autoantibodies in the blood. This causes blood to flow improperly and can lead to dangerous clotting in arteries and veins, problems for a developing fetus and pregnancy miscarriage. Plaquenil and valacyclovir Hydroxychloroquine side effects itching Approved for lupus by the Food and Drug Administration FDA in the 1950s, recent research suggests that Plaquenil may help lower the risk of a blood clot in people who have lupus and antiphospholipid antibodies. Plaquenil is “such a simple drug, and yet so powerful,” says Askanase. “It is the aspirin for lupus.” To receive a diagnosis of APS, patients must test serologically positive for at least one of the following on two occasions 12 weeks apart anticardiolipin antibodies, anti-beta-2-GPI antibodies aB2GPI and/or lupus anticoagulant. Of these, B2GPI may be the most relevant target of the antiphospholipid antibodies. Activation of the complement cascade might close the loop7 and provoke thrombosis and fetal loss 32-35occurs often in presence of a second hit. Traditional cardiovascular risk factors such as tobacco, inflammation, or oestrogens might have an important role at this point, in fact such risk factors are present in more than 50% of patients with antiphospholipid syndrome. APS affects women five times more commonly than men. People with this disorder may otherwise be healthy, or they also may suffer from an underlying disease, most frequently systemic lupus erythematosus (commonly called lupus or SLE). Plaquenil preeclempsis antiphospholipid Antiphospholipid antibody syndrome Lupus Foundation of America, Is Hydroxychloroquine Helpful for Patients with Antiphospholipid. Benlysta and plaquenilLong term use of hydroxychloroquine Antiphospholipid syndrome APS, an autoimmune systemic disease characterized by circulating antiphospholipid antibodies aPL, places women at risk of adverse pregnancy outcomes, such as recurrent pregnancy loss and late gestational complications including preeclampsia and associated premature delivery, HELLP syndrome hemolytic anemia, Hydroxychloroquine Prevents Antiphospholipid Antibody.. Antiphospholipid Syndrome during pregnancy the state of the art. Plaquenil and Antiphospholipid Syndrome - Reviews. What is antiphospholipid syndrome? Antiphospholipid syndrome APS is a systemic autoimmune disease characterized by production of antibodies – antiphospholipid antibodies aPL – that “attack” the person’s own body, resulting in blood clots and/or pregnancy complications. Antiphospholipid-antibody-positive patients also may develop other clinical problems. Objective. To investigate the effect of hydroxychloroquine HCQ in pregnant women with systemic lupus erythematosus SLE. Methods. In SLE pregnancies of a single Dutch center 2000–2015, lupus activity and flares before and during pregnancy and postpartum were assessed using the SLE Disease Activity Index SLEDAI/SLEPDAI SLEDAI adjusted for pregnancy. Other complications of pregnancy include dangerously high blood pressure preeclampsia and premature delivery. Stroke. A stroke can occur in a young person who has antiphospholipid syndrome but no known risk factors for cardiovascular diseases. Transient ischemic attack TIA.