I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Hydroxychloroquine dosing for sjogrens How does plaquenil treat lupus Plaquenil dangers Order aralen medication When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake. I've been taking prednisone for my rheumatoid arthritis, but I've heard that it can increase my chances of developing osteoporosis. How big is the risk? Answer From April Chang-Miller, M. D. Generally, the higher the dose of prednisone you take and the longer you take it, the greater the risk of osteoporosis. However, even low doses interfere. My Mom's Dr's wan'ts her to take both Prednisone and Plaquenil together. I have not heard of this being done. I was wondering if anyone has done both med's at the same time and the effects. Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil Prednisone MedlinePlus Drug Information, Osteoporosis and long-term prednisone What is the risk. Purpose of hydroxychloroquinePlaquenil pronunciation Like the others have said it's best not to take meds prescribed for reflux, such as Omeprazole or Lanzoprazole, at the same time as Plaquenil as they can make it less effective. I need to leave at least a couple of hours between my morning Lanzoprazole and my first dose of Plaquenil otherwise I feel sick. When best time of day to take plaquenil? - LUPUS UK. Prednisone and plaquenil -. Stopping Plaquenil and Cellcept when on Antibiotics. I started taking plaquenil actually the generic form about a month ago. I have noticed that I am starting to feel less pain and not as tired. I take methotrexate 4 pills a week and prednisone 7.5 mg a day. My main concern is the side effect on the eyes with plaquenil. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Re best time to take plaquenil. You take plaquenil twice a day, approximately 12 hours apart. The most common side effect is mild nausea and occasional stomach cramps. You can take it with food if it upsets your stomach. You should also have a complete eye exam before starting this medication and then every 6 months.