Using chloroquine to treat glioblastoma

Discussion in 'Canadian Pharmacy Online' started by RIU, 02-Mar-2020.

  1. stella_kris Moderator

    Using chloroquine to treat glioblastoma

    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention.

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    Jan 20, 2017 Because chloroquine has already earned FDA approval as a safe and effective and inexpensive treatment for malaria, the paper points out that it should be possible to “quickly test” the effectiveness of adding autophagy inhibition to a larger sample of BRAF+ glioblastoma and other brain tumor patients. If anyone has any experience with using the drug I would really appreciate your input on the following - I understand one of the main ways Chloroquine works is through inhibition of autophagy. Autophagy being an energy source for the tumour at a later stage when it is growing rapidly. Three cohorts of 3 patients will receive chloroquine in escalating doses 3 dose levels 200 mg up to 600 mg daily during standard treatment radiotherapy and temozolomide for newly diagnosed GBM. Extra patients can be added to a cohort in case of dose limiting toxicity, resulting in a maximum of 6 patients per dose level.

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Using chloroquine to treat glioblastoma

    Drug repurposing for the treatment of glioblastoma multiforme., Use of Chloroquine for glioblastoma, drug cocktail approach

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  5. Tional treatment regimens could not be adjusted for because of the small sample size. Conclusions Chloroquine may improve mid-term survival when given in addition to conventional therapy for glioblastoma multi-forme. These results suggest that larger, more definitive studies of chloroquine as adjuvant therapy for glioblastoma are warranted.

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    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine and related antimalarial drugs. This class of drugs has been widely used for decades in malaria prevention and therapy. These molecules are effective in blocking P. falciparum life cycle and are relatively well-tolerated. Recently, antimalarial drugs are also considered in cancer chemotherapy 84. Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme A Randomized, Double-Blind, Placebo-Controlled Trial. From the National Institute of Neurology and Neurosurgery of Mexico. From the National Institute of Neurology and Neurosurgery of Mexico.

  6. Rasih1 Guest

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine Uses, Dosage & Side Effects - Plaquenil is being used to treat Covid 19 lupus Plaquenil - Uses, Side Effects, Interactions -
  7. Jaz User

    Hydroxychloroquine se usa en el tratamiento o prevención de malaria, una enfermedad causado por los parasitos que entran al cuerpo a través de la mordida de un zancudo. Hydroxychloroquine Plaquenil Translation of Plaquenil in Spanish Plaquenil - English to Spanish Translation
  8. Grad XenForo Moderator

    Plaquenil Interactions - Antibiotics Home Page This could increase your risk for side effects or decrease the effectiveness of the medicines. To help prevent potentially negative Plaquenil drug interactions, tell your healthcare provider about all other medications you are taking before starting Plaquenil.

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