It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil effects on liver Retinal half life of plaquenil Plaquenil generic drug Hydroxychloroquine side effectt If I go off Plaquenil for 3 days or more I break out in my original symptom of huge hot welting hives from head to toe and fatigue like I've been hit by a Mack truck. I'm allergic to all NSAID's so I've only been able to take the narcotic pain meds, so I figure that I don't get the runs from the Plaquenil becuase the of the constipating effect. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens. I have not noticed an increase in depression/anxiety since being on the plaquenil but that is just me. I have only been on it for about a year now. Plaquenil and Bipolar disorder - from FDA reports Summary Bipolar disorder is found among people who take Plaquenil, especially for people who are female, 30-39 old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Psoriatic arthropathy. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and bipolar Hydroxychloroquine Plaquenil Side Effects & Dosage for., Plaquenil causing mood changes and depression? Chloroquine pillsPlaquenil 100mg tablet dosesHydroxychloroquine 347 So glad you posted this and I now know I'm not the only one having the crazy reaction to Plaquenil. I have RA and was put on Plaquenil 1 week ago and noticed the extreme moods swings, frustration turning to extreme rage, feeling crazy, then crying over my reactions. I really thought I was going nuts! My Rheumatologist Plaquenil Side Effects Of Bipolar And Depression.. Will you have Bipolar disorder with Plaquenil - eHealthMe. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. So glad you posted this and I now know I'm not the only one having the crazy reaction to Plaquenil. I have RA and was put on Plaquenil 1 week ago and noticed the extreme moods swings, frustration turning to extreme rage, feeling crazy, then crying over my reactions.