Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Aralens.ir Chloroquine raynauds This section of the Scleroderma FAQ is focused on standard treatment approaches that are designed either to target the overall disease process or to modify the disease in a way that can potentially improve more than one symptom, for example, bosentan Tracleer for skin ulcers and PAH. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. It's important to distinguish morphea from systemic scleroderma and other conditions. So your doctor may refer you to a specialist in skin disorders dermatologist or diseases of the joints, bones and muscles rheumatologist. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil Scleroderma and Systemic Sclerosis SSc An Overview - HSS.edu, Lupus and Scleroderma - Scleroderma News Chloroquine cell effectEye exam before plaquenilHydroxychloroquine cause ulcerExtreme hunger plaquenil I take Plaquenil for MCTD and it really helps my joint pain but it doesn't do anything for the more scleroderma - like features like Raynauds and GI issues, and It will not help Scleroderma lung problems. Plaquenil for scleroderma? - Scleroderma - Inspire. Morphea - Diagnosis and treatment - Mayo Clinic. Why Are Scleroderma Patients so Stubborn? - Scleroderma News. Drug-Induced Skin Itching Plaquenil, Minocycline, Many Others. Many medications can cause itching as either a minor or major side effect. Scleroderma patients, in particular, should never assume that itching is caused just by the disease. I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and doctor is a very good derm. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and.