Why chloroquine start with loading dose

Discussion in 'Chloroquine Online' started by bono, 13-Mar-2020.

  1. SET_4TM Moderator

    Why chloroquine start with loading dose

    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. -Each dose should be taken with a meal or a glass of milk.

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    Total maximum dose is 2.5 g chloroquine phosphate 1.5 g base in 3 days. The CDC recommends adding primaquine for P. vivax or P. ovale. The CDC recommends chloroquine as an option in uncomplicated malaria in patients with chloroquine-sensitive P. falciparum or P. vivax or in all patients with P. malariae, P. Loading dose is calculated by multiplying the desired peak concentration by the volume of distribution of the drug. If the dosing interval is the same as the half-life of the drug, the loading dose should be twice the maintenance dose i.e. after one half-life the drug concentration will have dropped by half. A number of studies demonstrate that creatine is safe over both short- and long-term periods 1, 2, 9, 10. According to the International Society of Sports Nutrition ISSN, up to 30 grams per day.

    -Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria. Use: Malaria prophylaxis Acute attack: 800 mg (620 mg base) orally followed in 6 to 8 hours by 400 mg (310 mg base), then 400 mg (310 mg base) once a day for 2 consecutive days; alternatively, a single dose of 800 mg (620 mg base) has also been effective Alternate dosing based on body weight: A total dose representing 25 mg/kg is administered in 3 days, as follows: First dose: 10 mg base/kg (not to exceed 620 mg base) orally Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose Third dose: 5 mg base/kg orally 18 hours after second dose Fourth dose: 5 mg base/kg orally 24 hours after third dose Comments: -Each dose should be taken with a meal or a glass of milk.

    Why chloroquine start with loading dose

    Hydroxychloroquine Dosage Guide with Precautions -, Maintenance dose and loading dose Deranged Physiology

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  7. Oct 01, 2018 Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Adult Dose The dosage for prophylaxis is 500 mg = 300 mg base administered once per week on exactly the same day of each week.

    • Chloroquine - FDA prescribing information, side effects and uses.
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    Nov 25, 2019 To treat malaria Chloroquine is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. To treat amebiasis Chloroquine is given in a high starting dose for 2 days followed by a smaller dose for 2 to 3 weeks. You may be given other medications to help prevent further infection. Dosage. Chloroquine can be administered either orally or parenterally for treatment of malaria, but prophylaxis is given in tablet form. An effective blood concentration is reached within 2-3 hours if a loading dose of 600 mg base is used. The therapeutically effective plasma concentration is 15-30 m g base/liter. The standard chloroquine dose for treating malaria in adults is a one-time loading dose of 1000 mg, followed by 500 mg in six to eight hours. Then 500 mg is taken once a day for two more days. The standard dosage for malaria treatment in children is based on the child's weight.

  8. KIV New Member

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  9. prm77 User

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil Hydroxychloroquine for Lupus - LupusCorner Plaquenil User Reviews for Systemic Lupus. - Lupus coronavirus risk? lupus
  10. krotov.dima Guest

    Hydroxychloroquine Oral Uses, Side Effects, Interactions. Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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