Chloroquine resistance mechanism of action

Discussion in 'Chloroquine Phosphate' started by absss, 04-Mar-2020.

  1. HUTOR Guest

    Chloroquine resistance mechanism of action


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. However, the fight against malaria becomes more difficult due to mosquitoes resistance to insecticides and Plasmodium falciparum strains which have developed increasing resistance to most of available antimalarial drugs. Chloroquine Nivaquine® was widely used as antimalarial drug and saved many lives for decades.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistance mechanism of action

    Chloroquine-Resistant Malaria The Journal of Infectious., Chloroquine - FDA prescribing information, side effects.

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  7. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. These 3Hquinoline compounds became associated with hemozoin.

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    Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely.

     
  8. YORRIK User

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Pepcid Tablets famotidine dose, indications, adverse. Pepcid, Act famotidine dosing, indications, interactions. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.
     
  9. dodgers Guest

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Mechanisms of action of hydroxychloroquine and chloroquine. Interactions between Plaquenil Oral and selected-cyp2d6. Psoriasis Causes & Triggers National Psoriasis Foundation
     
  10. jump Moderator

    Cause of nonallergic itch identified -- ScienceDaily Using the itch-inducing compound chloroquine, an antimalarial drug, the team identified that a family of proteins called Mrgprs, found only in a rare subset of nerve cells, functions as itch.

    Characterization of the chloroquine‐induced mouse model of.