Distribution of malaria and chloroquine-resistant

Discussion in 'Chloroquine Phosphate' started by remela, 19-Mar-2020.

  1. Distribution of malaria and chloroquine-resistant


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    The national strategy of malaria control involves early diagnosis and proper treatment to prevent mortality and to reduce morbidity, indoor residual spraying, distribution of insecticide-treated mosquito nets, and reactive and proactive case surveillance. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Distribution of malaria and chloroquine-resistant

    Malaria Prophylaxis. The ABCD of Malaria Prophylaxis., Chloroquine - Wikipedia

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  5. Jan 27, 2016 Distribution of Malaria and Chloroquine-resistant Plasmodium falciparum, 1993 Drug Resistance Resistance of P. falciparum to chloroquine has been confirmed or is probable in all countries with P. falciparum malaria except the Dominican Republic, Haiti, Central America west of the Panama Canal, Egypt, and most countries in the Middle East.

    • Malaria Health Information for International Travel.
    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.
    • Chloroquine Resistant Malaria –.

    Background. Both Plasmodium vivax and Plasmodium falciparum are prevalent in Pakistan, yet up-to-date data on the epidemiology of malaria in Pakistan are not available. This study was undertaken to determine the current prevalence and distribution of Plasmodium species across the country. The samples were processed and analysed using genes–P. falciparum chloroquine-resistant transporter pfcrt and P. falciparum multidrug resistance 1 pfmdr1 via sequencing of PCR amplicon from 2015 to 2017. Malaria occurred throughout the year and P. falciparum accounted for 89% of total malaria cases. TRAVEL TO AREAS WITH CHLOROQUINE-RESISTANT MALARIA. Chloroquine-resistant P. falciparum is found in all parts of the world except the Caribbean and countries west of the Panama Canal. Although chloroquine-resistant P. falciparum predominates in Africa, it is found in combination with chloroquine-sensitive P. vivax malaria in South America and Asia.

     
  6. maxchat.net.ru Moderator

    I have recently faced the cruel reality that my 120 gallon planted community Discus tank is infested with heat resistant/ treatment resistant ich. Aquarium Fish Chloroquine A "New" Drug for Treating Fish. Chloroquine Phosphate - Fish Medication Cryptocaryon - Wikipedia
     
  7. ZTG Moderator

    Chinese experts, based on the result of clinical trials, have confirmed that chloroquine phosphate, an antimalarial drug, has a certain curative effect on the novel coronavirus disease (COVID-19), a Chinese official said on Monday. Chloroquine Dosage Guide with Precautions - Chloroquine confirmed as anti-viral drug for Coronavirus Chloroquine MedlinePlus Drug Information
     
  8. Heretik Well-Known Member

    RA and Hydroxychloroquine How Effective is it for Rheumatoid. Does Hydroxychloroquine Have Side Effects? Like all medications, there is the risk of side effects. Fortunately, the problems seen by people taking this medication are usually very mild. Serious side effects are rare. Overall, most people who have any noticeable side effects from hydroxychloroquine experience diarrhea or nausea.

    Hydroxychloroquine Side Effects Common, Severe, Long Term.
     
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    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.

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