Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil and liver failure Does plaquenil treat inflammation Dengue is the most important arboviral disease in the world. As chloroquine, an antimalarial agent, has shown some antiviral effects, this study evaluated its effect in patients with dengue. A randomised, double-blind study was performed by administering chloroquine or placebo for three days to 129 patients with dengue-related symptoms. Chloroquine CQ, a cheap and well-tolerated drug, inhibits the growth of dengue viruses in the laboratory with concentrations achievable in the body. To measure the antiviral efficacy of CQ in dengue, we conducted a study involving 307 adults with suspected dengue. Patients received a 3-day oral dosage of placebo or CQ early in their illness. Apr 01, 2015 Dengue virus DENV of the Flaviviridae family is a single positive-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. The objective of this study was to investigate the use of chloroquine CLQ as an antiviral drug against dengue virus in monkeys. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine dengue Antiviral Activity of Chloroquine Against Dengue Virus., A Randomized Controlled Trial of Chloroquine for The trade name of chloroquine isChloroquine functional groups A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults. Tricou V1, Minh NN, Van TP, Lee SJ, Farrar J, Wills B, Tran HT, Simmons CP. Author information 1Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam. A randomized controlled trial of chloroquine for the.. Antiviral Activity of Chloroquine Against Dengue Virus Type 2.. Chloroquine, a FDA-approved Drug, Prevents Zika. The Effect of Chloroquine in the Treatment of Patients With Dengue The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Jan 23, 2017 By increasing endosomal pH, chloroquine inhibits dengue virus type 2 replication DENV‐2in Vero cells Farias et al. 2013, and U937 cells Farias et al. 2014 at a nontoxic dose of 50 μg/mL in vitro.