Chloroquine phosphate chemical formula

Discussion in 'Chloroquine Without A Doctors Prescription' started by Irena_spb, 02-Mar-2020.

  1. -=Eva=- Well-Known Member

    Chloroquine phosphate chemical formula


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by thin-layer chromatography TLC and liquid chromatography LC. These Secondary Standards are qualified as Certified Reference Materials. Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Chloroquine is related in structure to quinine but more potent against Plasmodium falciparum, ovale, malariae and vivax, and better tolerated than quinine. Chloroquine remains the first choice of antimalarial prophylaxis as well as treatment. Chloroquine is available in tablets of 250 and 500 mg in generic forms and under the brand name Aralen.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine phosphate chemical formula

    Chloroquine - brand name list from, Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR.

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  6. Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial and anticancer activities. 1,2,3 Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 µM. 1 It is active against the chloroquine-sensitive GC03 strain of P. falciparum IC 50 = 29.2 nM but has decreased.

    • Chloroquine phosphate - Cayman Chemical.
    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Chloroquine diphosphate C18H32ClN3O8P2 ChemSpider.

    Chemical formula of Chloroquine phosphate The drug proved effective at treating and also preventing malaria for decades before malarial parasites developed resistance to it. Xinhua, the state-run news agency, also reports that chloroquine has been used in clinical trials in more than 10 hospitals in China’s capital, Beijing, and two other provinces and “has shown fairly good efficacy”. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. The chemical name of chloroquine phosphate in chemical abstracts is found under the heading Quinoline and designated as 7-Chloro- 4-4-diethylamino-1-methylbutylamino quinoline diphosphate. Chloroquine phosphate is a white, odorless, crystalline powder having a bitter taste it discolors gradually on exposure to light.

     
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    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine-Resistant Malaria The Journal of Infectious. Chloroquine - FDA prescribing information, side effects and uses Drug Resistance – Malaria Site
     
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