Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and pregnancy side effects Sideeffects of plaquenil Chloroquine phosphate and hydroxychloroquine sulfate are substituted 4-amino quinoline compounds that differ only by a hydroxy group. Quinacrine hydrochloride also has the 4-amino quinoline radical but has, in addition, a benzene ring; it is classified as an acridine compound. THIS study was undertaken as a clinical evaluation of the treatment of lupus erythematosus with a tablet composed of quinacrine, 25 mg. hydroxychloroquine, 50 mg. and chloroquine, 65 mg. The benefit of combining quinacrine Qn with hydroxychloroquine HCQ in the treatment of systemic lupus erythematosus SLE was previously re-evaluated by us. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Quinacrine with hydroxychloroquine Antimalarial agents. Chloroquine, hydroxychloroquine, and., Lupus Erythematosus Treated with a Combination of Quinacrine. Chloroquine-induced pigmentation Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Hydroxychloroquine - Wikipedia. Quinacrine and hydroxychloroquine, a forgotten combination.. Quinacrine in the Treatment of Cutaneous Lupus Erythematosus.. Quinacrine is used as second-line therapy in patients with pre-existing eye problems that contraindicate treatment with chloroquine or hydroxychloroquine after evaluation of which drug has the. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEPACRINE HYDROCHLORIDE. The antimalarial drugs chloroquine, hydroxychloroquine and quinacrine are reviewed with respect to the history of their use, pharmacokinetics, mode of action DNA interactions, melanin binding, anti-inflammatory, immunosuppressive, sunscreen effects, toxicity cutaneous, haematological, neuromuscular, ocular and usage.