Hydroxychloroquine american academy of ophthalmology

Discussion in 'Chloroquine' started by adm21, 11-Mar-2020.

  1. odio New Member

    Hydroxychloroquine american academy of ophthalmology


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Ophthalmology. 2011 Oct;118102100; author reply 2101. BACKGROUND The American Academy of Ophthalmology recommendations for screening of chloroquine CQ and hydroxychloroquine HCQ retinopathy were published in 2002, but improved screening tools and new knowledge about the prevalence of toxicity have appeared in the ensuing years. Given the emergence of more sensitive diagnostic techniques and the recognition that risk of toxicity from years of hydroxychloroquine use is greater than previously believed, the American Academy of Ophthalmology has released updated guidelines on screening for retinopathy associated with hydroxychloroquine toxicity. In 2011, an American Academy of Ophthalmology committee published revised guidelines concerning screening for hydroxychloroquine toxicity. 1 Previous guidelines had been published in 2002. guidelines recommend a baseline examination at onset of therapy that should include macular static perimetry eg, the Humphrey 10-2 visual field 10-2 VF and at least 1 of multifocal.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Hydroxychloroquine american academy of ophthalmology

    Monitoring for hydroxychloroquine retinopathy Eye, Chloroquine and Hydroxychloroquine Toxicity Workup Approach.

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  6. Background/Purpose Hydroxychloroquine HCQ induced retinal toxicity remains a major concern because it can lead to irreversible damage to retinal pigment epithelium and blindness. American Academy of Ophthalmology AAO 2016 guidelines recommend to use HCQ at dosages ≤5 mg/kg real body weight to minimize toxicity 1.

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    Background/Purpose Hydroxychloroquine HCQ is an antimalarial agent used commonly to treat selected autoimmune rheumatic diseases because of its therapeutic benefits, low cost, and favorable safety profile. While minor side effects may occur, the most feared toxicity is retinal thinning with irreversible loss of vision. The February 2011 American Academy of Ophthalmology AAO Revised. Dec 04, 2014 Hydroxychloroquine HCQ retinopathy can result in permanent vision loss. In early stages of HCQ retinopathy, patients are usually asymptomatic with preservation of visual acuity. We aspire that our review, in conjunction with the American Academy of. The specific recommendation of the American Academy of Ophthalmology is for a baseline examination listed in table 2 2 for all patients starting HCQ treatment. Unfortunately, there is no “gold standard” for identification of toxicity before the development of the ophthalmoscopic changes that is, pigmentary changes and “bull’s eye maculopa

     
  7. trink Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Drugs & Medications - WebMD Psoriasis Causes & Triggers National Psoriasis Foundation
     
  8. KraBZburger Well-Known Member

    Chloroquine treatment of ARPE-19. - PubMed Central PMC Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively. Dilation is an indicator of lysosomal dysfunction.

    Chloroquine Indications, Side Effects, Warnings -