Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. How does plaquenil help inflammation Lorazepam and hydroxychloroquine Chloroquine proguanil boots The study showed that the combination of methotrexate and hydroxychloroquine is equivalent to leflunomide in improving the disease activity and is similar in the hepatic safety profile. We conclude that methotrexate in combination with hydroxychloroquine is equal in efficacy to new drug leflunomide as an initial therapy in severe active rheumatoid arthritis. Patients received treatment with leflunomide and methotrexate and 133 subjects were randomized to placebo and methotrexate. The response rate of ACR20 criteria P0.001 at week 24 was 46.2% and 19.5% for the leflunomide and placebo groups respectively. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and leflunomide together Hydroxychloroquine - Side Effects, Dosage, Interactions., The Combination of Leflunomide. - Arthritis Information Common side effects of plaquenil Safety and efficacy of hydroxychloroquine to treat lupus and arthritis have not been established in children. Geriatric. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydroxychloroquine in the elderly. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. RA and Hydroxychloroquine How Effective is it for.. . Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Although the precise mechanisms of action of the traditional DMARDs are incompletely understood, most have both anti-inflammatory and immunomodulatory actions. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight.