Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. How does plaquenil affect lichen planus Baseline labs required before starting plaquenil Plaquenil and eoe Well I was just in on Wednesday and my one leg hurts so bad I can hardly walk which apparantly is from osteoarthiritis which I forgot I had too, anyways to make a long story short. I have so much inflammation in my leg she said if I cant take both of the Plaquenil tablets it does me no good, its a waste of money. Sep 19, 2010 Does anyone else feel worse on Plaquenil. and it makes that flu feeling worse for me. That's what I'm trying to get rid of. the Plaquenil and feel better. I. Some of the most common drugs that can make you tired are Allergy medications antihistamines, such as diphenhydramine, brompheniramine Bromfed, Dimetapp, hydroxyzine Vistaril, Atarax, and meclizine Antivert. Some of these antihistamines are in sleeping pills, too. Plaquenil is used to treat other types of infections too. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil makes me tired Will you have Fatigue with Plaquenil - eHealthMe, Does anyone else feel worse on Plaquenil? Chloroquine weeklyDiscontinuing plaquenil now have muscle spasms Plaquenil doesn't seem to make me sleepy. I take it twice a day and have for year. In the beginning it made me nauseated and dizzy. I lowered the dose for awhile and took it with food. Now it doesn't bother my stomach at all. I know when my lupus is bad I am extremely tired all the time. So, maybe it's the lupus. Plaquenil tiredness/weakness ? DailyStrength. Medications That Can Cause Fatigue & Drowsiness. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. I take Plaquenil along with prednisone, methotrexate, and Humira. None of these meds make me fatigued. I believe its the illness that causes my fatigue and my daughters fatigue. I suspect that holds true for you too. Maybe someone else will tell you differently, but I haven't known anyone else that found Plaquenil to make them tired. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Re plaquenil for vasculitis They are getting ready to start the methotrexate this week on Wednesday to go with the plaquenil. I went get a base line from the opthalmologist before I started the plaquenil and he told me to do a simple test everyday and see him twice a year and it would be ok and get caught early if it starts to bother my eyes.