After only 6 weeks, and barely taking half of the supplement "prescription", because I started having reflux, etc. Not entirely sure yet, and to be fair - I've been on Plaquenil since last December. Along with flare and had to back off the vitamins numerous times - nevertheless my cholesterol profile improved tremendously (triglycerides alone came down a whopping 400 points! The doctor cites the malabsorption due to the celiac as the main reason for my osteoporosis and what he called "adult rickets", and my bad cholesterol profile, especially triglycerides comes from Vit B deficiency. Pill plaquenil generic dog bone shapped Neurontin and plaquenil interactions Dec 27, 2010 But have been on Medrol, Plaquenil, and only a short time of Cellcept. My ANA went neg. But since they weaned me from 10 mg Medrol to 8- then had the eye problems, chills, diarrhea, etc, then to 6 mg, again with chills, eye problems, etc, the ANA went to 40 then 80 which I know is very low compared to before, but why does it do this? For several years I have had recurrent unexplainable illnesses, rashes and arthritis-like symptoms. Finally during my last episode, I requested an ANA test, which returned positive. My doctor and I both felt like we were finally getting to the bottom of things and he referred me to a rheumatologist, but by the time I could get in to see him, I was well again 6 weeks. The rheumatologist was. Jun 18, 2010 Thank you Lynnwood and Redrose for your responses; they are validating to me. It all makes sense, but it seemed so extreme. To have a positive ANA for so long that suddenly became negative seemed strange to me. Yes, I have been taking Plaquenil since I was diagnosed--so going on four years now. I've had less aches and pains since taking triple strength fish oil. Still get fatigued and seem to have flares involving my stomach every 1 - 2 weeks since starting all of this, so I'm investigating and trying to rule out possible causes of that (one of which might be the pharmacy's switch to a different manufacturer of my generic Plaquenil that occurred at the same time). I've been doing a lot of reading and information gathering regarding celiac disease and autoimmune disease and there are so many links! ) My Vit D improved from 17 to 26 (I barely took any Vit D) a high parathyroid level returned to a normal range, and my ANA was negative for the first time in 3 years. I've never been able to stay on a statin drug - all caused major side effects. Can plaquenil cause a negative ana Hydroxychloroquine Side Effects, Dosage, Uses, and More, Positive ANA Turned Negative - Arthritis Information Drug interactions between hydroxychloroquinePharmacokinetics of quinine chloroquine and amodiaquinePhototoxic reaction to plaquenil Certain medications can also cause an ANA test to be positive as can some infections and liver diseases. A positive ANA isn’t specific for lupus, since the test can also be positive with other autoimmune diseases as well. If an ANA test is negative, the diagnosis of SLE is less likely, but the small possibility of having the disease is still. Is It Common to Have Lupus with a Negative ANA Test?. Positive ANA at 80 and now negative.. Why hydroxychloroquine can treat primary ITP with positive.. I know that there are many causes for a positive ANA, but does a negative ANA mean someone doesn't have lupus? Is there cause for these doctors to change their minds, or is it that many doctors just know so little about lupus, that they doubt their original dx? It would be great if you could shed a little light on this for all of us. Plaquenil can also cause your test results to be inaccurate as it works as an anti-inflamatory for an auto-immune disease lupus, aps. Just know that ANA tests arent always accurate. The levels can vary from week to week depending on your body or a flare up/non flare up. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. which can cause allergic reactions.