Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil tablets 200mg Is generic plaquenil as good Celebrex and plaquenil Chloroquine. Uses. Chloroquine is used in the treatment or prevention of malaria. How it Works. Malaria typically enters the body through the bite of a mosquito. Chloroquine works by interfering with the growth of Malaria parasites in the red blood cells of the human body. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine cholesterol Hydroxychloroquine Uses, Dosage & Side Effects -, Chloroquine C18H26ClN3 - PubChem Chloroquine mechanism of action slideshareNight swets plaquenilPlaquenil retinal damageWhat does plaquenil depletePlaquenil drug reviews Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells Skip to main content Thank you for visiting Inhibition of cholesterol metabolism underlies synergy.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Chloroquine. The lipid droplet LD is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis. Cholesterol, stored as cholesteryl esters CEs, is liberated from this organelle and delivered to cholesterol acceptors. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. According to the researchers, chloroquine is a potential solution to bridge this gap. In part because chloroquine is cheap, relatively easy to produce in larger quantities and has been on the market for more than 85 years. The Chinese government has confirmed that chloroquine has a certain curative effect on the novel coronavirus disease.