It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine and slurred speech Plaquenil 3 times a week The safety and efficacy of the chronic use of hydroxychloroquine for systemic lupus erythematosus and juvenile idiopathic arthritis in children and infants have not been established. Children are especially sensitive to the 4-aminoquinoline compounds. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. To treat lupus erythematosus, the average adult dose is 400 mg once or twice daily. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine pediatric lupus Hydroxychloroquine Plaquenil, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Does plaquenil change heart rateHydroxychloroquine dose medscape In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis. Drug spotlight on hydroxychloroquine Lupus Foundation of America. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. The future. Hydroxychloroquine was previously prescribed only for people whose lupus disease activity was mild in its course; if the lupus became active, steroids or immunosuppressants would be prescribed instead. Today, however, HCQ is recommended for most individuals with lupus, whether mild, moderate, or severe. Systemic lupus erythematosus lupus is a chronic autoimmune disease characterized by inflammation, pain and swelling. A healthy immune system protects your child from infection by attacking invaders such as viruses or other pathogens. In children with lupus, the immune system mistakenly attacks the body's own cells and tissue, causing. Hydroxychloroquine. Hydroxychloroquine is an antimalarial agent given to almost all patients with adult or pediatric SLE. Hydroxychloroquine inhibits Toll-like receptor pathways and minimizes flare, treats skin disease, and decreases the rate of autoantibody production 13, 14. The usual prescribed dose of hydroxychloroquine is 4–6/mg/kg/day.