If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Beau's lines plaquenil Homocysteine plaquenil Side effects stopping plaquenil Chloroquine rheumatoid arthritis mechanism of action Again, calculating "safe" daily plaquenil dosage for this weight 66.02 kg * 6.5 mg/kg/qd = 429 mg. As expected, it indicates a higher "safe" dosage 429 vs 356mg than the calculation using ideal body weight for this height. For the last time, let's graph this relationship to get a look at the big picture The median weight was 160 pounds 72.7 kg, IQR 133, 185 pounds, range 90, 330 pounds. Twenty-nine percent of women were less than or equal to 63 inches tall 160 cm, a threshold height for potentially toxic dosing based on consumption of 400 mg hydroxychloroquine per day and a commonly used IBW algorithm. Ideal Body Weight for Calculating Hydroxychloroquine Dosage. The most important risk factor for hydroxychloroquine retinopathy is the daily dose of the drug. If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range /= 6.5 mg/kg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dosing ideal body weight Protecting your eyesight when taking Plaquenil Lupus., The impact of different algorithms for ideal body weight. Do you still have flare ups while taking hydroxychloroquineTaking melatonin with hydroxychloroquinePlaquenil and eye damagePlaquenil alt levelsHow can plaquenil scarring alopecia Furthermore, the co-authors found that the prevalence of toxicity relative to real body weight dosing was independent of body habitus, while thin individuals dosed by ideal body weight had a much. Despite Plaquenil dosing recommendations, retinal toxicity remains. Ideal Body Weight for Calculating Hydroxychloroquine Dosage - The.. Protecting your eyesight when taking Plaquenil Lupus Foundation of.. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. Since Plaquenil distributes in lean tissues and not fat, theoretically I would think they'd be at lower risk of toxicity, and I wonder if it may be better to use ideal body weight IBW instead for them. Per ideal body weight calculations, a man who weighs 135# or more and who is not obese should be on 400 mg a day. Child dosage ages 0–17 years Acute attack Dosage is based on body weight. The typical starting dose is 13 mg/kg maximum dose 800 mg.