Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Symptoms of plaquenil toxicity What happens when yoou stop taking hydroxychloroquine abruptly Plaquenil crohn's disease Drugs for ra plaquenil and Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. My Dr. prescribed Plaquenil the other day, I took 2-200mg pills in a 24 hr period and I was sick as a dog. I had stomach cramps, nausea and painful diarrhea, not to mention heart palpitations and an all over uneasiness. By the end of the 24 hrs I had also contracted a chest cold. Needless to say it was a rough couple of days. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil causes nausea Will you have Nausea with Plaquenil - eHealthMe, Hydroxychloroquine Plaquenil Plaquenil retinal toxicity treatment Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. I do think you should let your rheumy know. Plaquenil = explosive diarrhea -. Plaquenil & Nausea - Autoimmune diseases - Inspire. Is extreme fatigue a side effect of Plaquenil?. Hello, I was recently told by my internal medicine doctor, after years of cataloging symptoms, that she was going to begin treating me for Lupus. She started me on the generic version of Plaquenil at 200 mg. I have had a really hard time on this medicine. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. By janlorraine December 15, 2015 at am. After every side effect possible, I finally stopped taking 200mgs of Plaquenil after dinner every day. Now four days later I am still so nauseated I can barely function and I am also still getting horrible headaches and cramps.