It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Doea plaquenil affect the immune system Plaquenil helping intestinal inflammation Plaquenil patient reviews Increasing plaquenil dose Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Hydroxychloroquine plaquenil and sulfasalazine azulfidine are used for mild rheumatoid arthritis. they are not as powerful as other dmards, but they usually cause fewer side effects. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work What are the side effects of hydroxychloroquine and., What are the side effects of using hydroxychloroquine. Is hydroxychloroquine a painkiller For children, sulfasalazine should only be started by a specialist. Sulfasalazine won’t start to work immediately, and it could be at least 12 weeks before you notice any effects. You shouldn’t take sulfasalazine if you’re known to have an allergy to salicylates. Salicylate is a natural chemical that is found in some foods. Sulfasalazine Side-effects, uses, time to work. Methotrexate, Plaquenil or Sulfasalazine Azulfidine. - Inspire. Compare Plaquenil vs Sulfasalazine -. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Hey everyone! Is anyone here with psoriatic arthritis just taking plaquenil or sulfasalazine or both together? I’m curious to know if these drugs can individually or mutually be enough to control inflammatory symptoms. Optimal use of disease‐modifying antirheumatic drugs DMARDs in rheumatoid arthritis is vital if progression of disease is to be reduced. Methotrexate MTX and sulfasalazine SASP are widely used inexpensive DMARDs, recently often combined despite no firm evidence of benefit from previous studies.