Chloroquine intercalating

Discussion in 'International Pharmacy' started by nevabank, 26-Feb-2020.

  1. 2r User

    Chloroquine intercalating

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Purpose Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies Neurosurgical Focus 142 February, 2003 and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine intercalating

    DNA Interaction and Dual Topoisomerase I and II Inhibition., Chloroquine Oral Uses, Side Effects, Interactions.

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  4. Chloroquine could also be acting directly on DNA, altering the expression of Plasmodium genes. Early work on this drug has shown that chloroquine can act as DNA-intercalating agent 19 and this mechanism was used to explain the antimalarial effect of the drug 20.

    • Background The anti-malarial chloroquine can modulate the..
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    Antimalarial drug chloroquine. This activity was mitigated by the addition of plasmid DNA, suggest-ing that these compounds act against parasites by intercalating into their DNA. Key words antimalarial agents; quinomycin A; DNA intercalation Malaria is one of the most serious infectious diseases in many tropical and subtropical countries. Due. Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. Chloroquine, like other intercalators, may work by altering three-dimensional structure. For exam- ple, there is evidence that DNA may form left-handed helices Z-DNAin transcriptionally active regions. We have found that chloroquine prevents the transition of DNA to the Z form in vitro, at concentrations as low as 20 Ref. 17.

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