Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Hydroxychloroquine indications and contraindications When was chloroquine invented Oct 01, 2018 Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. The nurse will explain which of the following regimens of chloroquine prescribed by the physician? Taking the medication for 2 weeks before the trip and for 4 to 6 weeks after the trip. Which drug is currently the mainstay of antimalarial therapy? Chloroquine Aralen Chloroquine-sensitive uncomplicated malaria Plasmodium species or species not identified 600 mg base 1 g salt orally at once, followed by 300 mg base 500 mg salt orally at 6, 24, and 48 hours Total dose 1.5 g base 2.5 g salt Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Regimens of chloroquine Recommendations for the Prevention of Malaria Among Travelers, Chapter 12 quiz Flashcards Quizlet Skin changes with plaquenilMacular scar tissue plaquenilHydroxychloroquine induced cardiomyopathy and heart failure in twinsIs plaquenil an anti inflammatoryPlaquenil sleep disturbance Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor. Chloroquine Oral Route Proper Use - Mayo Clinic. Chloroquine Dosage Guide with Precautions -. Safety and Efficacy of Different Regimens of Primaquine on.. Nov 15, 2015 Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. In addition, any of the regimens listed below for the treatment of chloroquine-resistant malaria may be used for the treatment of chloroquine-sensitive malaria. Prompt initiation of an effective regimen is vitally important and so using any one of the effective regimens that is readily at hand would be the preferred strategy. Chloroquine can be used to treat porphyria cutanea tarda, but in a very low dose 125 mg twice weekly as a dosage of 250 mg/day can trigger a porphyria crisis, which can be fatal. Chloroquine is contraindicated where there is a known hypersensitivity to 4-aminoquinoline compounds.