Chloroquine retinopathy after drug cessation

Discussion in 'North West Pharmacy Canada' started by Flag, 08-Mar-2020.

  1. WMpaK XenForo Moderator

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    However, in a number of patients, early retinopathy macular pigmentation sometimes with central field defects diminished or regressed completely after therapy was discontinued. Paracentral scotoma to red targets, sometimes termed PREMACULOPATHY, is indicative of early retinal dysfunction and is usually reversible with cessation of therapy. Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. A detailed patient history that confirms chloroquine use is essential, while advanced ophthalmologic methods must be employed to assess the status of the retina. After the cessation of chloroquine treatment, early subtle macular changes can revert to normal. Although far advanced cases may progress despite discontinuation of the drug, most patients remain stable with long-term follow-up. 41,42 Chloroquine, however, is very slowly excreted from the body.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Long-term continuation of chloroquine-induced retinal., Chloroquine Retinopathy Symptoms, Diagnosis and Treatment.

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  6. Jan 05, 2020 In general, hydroxychloroquine and chloroquine retinopathy are not reversible, and even following drug cessation, cellular damage appears to continue for a certain period of time. However, the earlier the retinopathy is recognized, the greater the chance of visual preservation. Keratopathy has been reported to be fully reversible. References

    • Hydroxychloroquine toxicity - EyeWiki.
    • Chloroquine Retinopathy - an overview ScienceDirect Topics.
    • Long-Term Course of Chloroquine Retinopathy after Cessation..

    Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less. Thirty eyes with HCQ retinopathy were followed with SD-OCT after drug cessation. Findings before disruption of the parafoveal EZ included parafoveal outer nuclear layer ONL thinning, disruption of the parafoveal interdigitation zone, and reduced reflectivity of the parafoveal EZ. Jul 30, 2019 Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy.

     
  7. muzabbar Guest

    : September 14, 2016 Chief complaint: Whirling and flashing lights A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. Hydroxychloroquine Retinopathy Still Alive and Well - Page. How to Succeed in Plaquenil Screenings Multimodal Imaging in Plaquenil Toxicity
     
  8. manager_007 Moderator

    Assessment of in vitro prophylactic and therapeutic efficacy. Efficacy of Chloroquine Against Chikungunya Virus in Vero Cells Mohsin Khan, S. R. Santhosh, Mugdha Tiwari, P. V. Lakshmana Rao, and Manmohan Parida* Division of Virology, Defence Research & Development Establishment DRDE, Gwalior, MP, India The resurgence of Chikungunya virus CHIKV in the form of unprecedented and explosive epi-

    CuraChik A Trial of the Efficacy and Safety of.
     
  9. glintwine XenForo Moderator

    Suicide by Salt hypernatremia TERMINAL DECISION Chloroquine & Diazepam Pentobarbital & Paspertin Cyanide Bitter almonds etc. Caffeine pills, powder etc. Alcohol Hanging Strangulation Broken neck Beheading Shock the public Self Immolation Jumping Beheading Suicide by cop Death by train Hydrogen Sulfide “H2S” Electricity

    He jumped off the Golden Gate Bridge and survived. Now, he.