Curvilinear bodies hydroxychloroquine cardiomyopathy

Discussion in 'North West Pharmacy Canada' started by dimitriy2008, 27-Feb-2020.

  1. Flyleaf Guest

    Curvilinear bodies hydroxychloroquine cardiomyopathy


    However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. We present a case of twin sisters who both suffered from systemic lupus erythematosus (SLE) and HCQ-induced cardiomyopathy presenting with decompensated heart failure (HF), suggesting that genetic predisposition might be a factor in HCQ-induced cardiomyopathy.

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    Hydroxychloroquine and chloroquine are often used for long-term treatment of rheumatic diseases and for malaria prophylaxis. Hydroxychloroquine- and chloroquine-induced cardiomyopathy have well-described microscopic features, with the classic electron microscopic findings of myelin figures myeloid bodies. Final Diagnosis -- Hydroxychloroquine myopathy. Hydroxychloroquine myopathy. Hydroxychloroquine HCQ, a commonly used drug for various autoimmune conditions, is widely distributed into cardiac and skeletal muscle tissue. It is a large amphiphilic molecule that can cause both myofiber necrosis and vacuolar myopathy. Endomyocardial biopsy demonstrated myeloid bodies admixed with curvilinear bodies, most consistent with a diagnosis of HCQ toxicity. This case illustrates the importance of clinical integration of multiple causes of cardiomyopathy, recognition of HCQ cardiotoxicity, and increased uncertainty in genetic test findings among racial minorities.

    Retinal toxicity, neuromyopathy, and cardiac toxicity are recognized toxicities following prolonged use (1). Hydroxychloroquine (HCQ) is one of the antimalarial drugs that have been used for decades to treat rheumatic diseases (1).

    Curvilinear bodies hydroxychloroquine cardiomyopathy

    Hydroxychloroquine Professional Patient Advice -, Final Diagnosis -- Hydroxychloroquine myopathy - UPMC

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    Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy key diagnostic features and literature review. Curvilinear bodies in particular appear to be the most specific histological indicator of antimalarial-related cardiotoxicity and these structures are not seen in differential diagnoses of some of. Hydroxychloroquine myopathy is thought to be underestimated with prior reports noting normal CK levels in patients with typical biopsy features of vacuoles and curvilinear bodies. Duration of drug and dose are not well defined in myopathy; onset of symptoms may vary months to years; typical symptoms are nonspecific mild to moderate proximal muscle weakness with slightly elevated to normal CK levels. HCQ neuromyotoxicity is a rare complication characterized by proximal muscle weakness, normal creatinine kinase levels, and characteristic ultrastructural changes on muscle biopsy of curvilinear body formation.

     
  8. Candy Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Hydroxychloroquine MedlinePlus Drug Information Aralen Chloroquine Side effects, Images, Uses, Dosage. Hydroxychloroquine - Wikipedia
     
  9. EvgRen New Member

    Tizanidine Oral Route Before Using - Mayo Clinic Breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Drug Interactions

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses