Chloroquine nuclei acid biosynthesis

Discussion in 'Northwest Pharmacy Canada' started by CY4KA, 24-Feb-2020.

  1. Stacy New Member

    Chloroquine nuclei acid biosynthesis


    Indeed, the ability to salvage nucleotides from sources within the body alleviates any significant nutritional requirement for nucleotides, thus the purine and pyrimidine bases are not required in the diet. The salvage pathways are a major source of nucleotides for synthesis of DNA, RNA and enzyme co-factors.

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    Co-treatment with ascorbic acid has prevented both chloroquine-induced ROS production and chloroquine toxicity on glial cell cultures. This pre-clinical study is the first one to demonstrate chloroquine-induced ROS production by glial cells of inner ear as well as the protective effect exerted by ascorbic acid on these cells. NNuucclleeiicc AAcciiddss Nucleic acids are molecules that store information for cellular growth and reproduction There are two types of nucleic acids - deoxyribonucleic acid DNA and ribonucleic acid RNA These are polymers consisting of long chains of monomers called nucleotides A nucleotide consists of a nitrogenous base, pentose sugar and a phosphate group. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

    Following their synthesis in the liver the nucleotides are dephosphorylated and in part phosphorolytically cleaved into nucleobases and ribose-1-phosphate for transport to the blood and then subsequent uptake by cells of the other organs. Within the body the major site of de novo nucleotide synthesis, for the replenishment and maintenace of intracellular pools, is the liver.

    Chloroquine nuclei acid biosynthesis

    Nucleic acids article Khan Academy, Nucleic Acids ppt -

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  6. Abstract. 1 Chloroquine, primaquine and ethidium inhibitied thymidine incorporation into deoxyribonucleic acid of rat tissues when administered concurrently with the labelled precursor. 2 Chloroquine and primaquine inhibited the incorporation of uridine and adenine, but not orotate, into various ribonucleic acid fractions of liver of rats and mice.

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    IMP, whose de novo biosynthesis we have just seen, is not a normal con­stituent of nucleic acids; it will be converted into adenylic and guanylic nucleotides, which are the major purine nucleotides found in ribonucleic and deoxyribonucleic acids. These transformations are diagrammatically depicted in figure 6-21. Nucleic acid metabolism DNA metabolism. Replication, repair, and recombination—the three main processes of DNA metabolism—are carried out by specialized machinery within the cell. DNA must be replicated accurately in order to ensure the integrity of the genetic code. Errors that creep in during replication or because of damage after replication must be repaired. Nalidixic acid tradenames Nevigramon, Neggram, Wintomylon and WIN 18,320 is the first of the synthetic quinolone antibiotics. In a technical sense, it is a naphthyridone, not a quinolone its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.

     
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