Additionally, another exception occurred while executing the custom error page for the first exception. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Hydroxychloroquine and swollen lymph nodes G6pd deficiency hydroxychloroquine This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Photopsia plaquenil toxicity Recommendations on Screening for Chloroquine and Hydroxychloroquine., Plaquenil Risk Calculators Chloroquine pharmacological classWhat do hydroxychloroquine doHydroxychloroquine memory lossPlaquenil alopecia areata Photopsia perception of flashes or flickering light. Progressive hydroxychloroquine toxicity mimicking low-tension glaucoma after discontinuation of the drug. Hydroxychloroquine-related retinal toxicity Rheumatology Oxford.. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening. Chloroquine and Hydroxychloroquine • LITFL • Toxicology Library Toxicants. Plaquenil hydroxychloroquine is a medicine commonly used to treat patients with systemic lupus erythematosus and rheumatoid arthritis. After prolonged use, it can sometimes damage the macula and cause central vision loss. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.