Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil cause leg cramps Plaquenil et lyme Best alternative to plaquenil Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Get medical help right away if you have any very serious side effects, including chest pain, fast/irregular heartbeat, severe dizziness, fainting, seizures. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects right away The Risk of Retinal Toxicity with Plaquenil, Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Chloroquine toxicity of retina Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you or your child have any of the following symptoms while using this medicine blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. What is Plaquenil? - GoodRx. Plaquenil Side Effects - GoodRx. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy.. Plaquenil is supposed to stay in your system for 1-2 months after you stop taking it. Try to rest, stay hydrated and away from sick ppl for now and hopefully you will not have any issues ranin02 Jan 11, 2012 I have been on the plaquenil 200 mgm for about 4 months now. I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Noticed nothing different. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. If you experience any of the following symptoms, call your doctor immediately reading or seeing difficulties words, letters, or parts of objects missing. sensitivity to light. blurred distance vision. seeing light flashes or streaks. difficulty hearing. ringing in ears. muscle weakness.