She reported that the blurriness was in both eyes, and it was slowly progressive over the past few months. She had a medical history of high blood pressure, high cholesterol, and rheumatoid arthritis. Plaquenil for lupus rash Symptoms of plaquenil eye problems Plaquenil can they be cut in half Hydroxychloroquine and bloating Risk of HCQ toxicity was then assessed in tertiles defined by these variables. The duration of hydroxychloroquine use years in tertiles by distribution and its association with HCQ toxicity were also examined. Results The risk of HCQ toxicity is shown in Table 1. Table 1. Risk of HCQ retinal toxicity by variable. IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy. Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. Risk Factors. There are risk factors which may increase the likelihood of an individual in developing symptoms of Plaquenil toxicity 1. Her visual acuity with habitual Rx at distance was 20/40 OD and 20/50-OS, while at near was 20/40. She was currently taking 81 mg aspirin, atorvastin (Lipitor, Pfizer), Centrum Silver multivitamin, fish oil, hydroxychloroquine (Plaquenil, Concordia) 200 mg QD, isosorbide mononitrate (Imdur, Hikma), levetiracetam (Keppra, Pfizer), Nitrostat (nitroglycerin, Pfizer), Restasis (cyclosporin, Allergan), Ranexa (ranolazine, Gilead), Trexall (methotrexate, Teva), citalopram (Celexa, Forest Labs), losartan/hydrochlorothiazide (Hyzaar, Merck), sulfamethoxazole/trimethoprim (Bactrim DS and topiramate (Trokendi XR, Ortho-Mc Neil). Hydroxychloroquine retinopathy risk Retinal Physician - Hydroxychloroquine Maculopathy An Update., The risk of toxic retinopathy in patients on long-term. Hydroxychloroquine nursing teaching5 line raster oct plaquenilPlaquenil treatment for rheumatoid arthritis Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Plaquenil Risk Calculators. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. This is the first study that focuses on assessing retinopathy risk by tracking hydroxychloroquine blood levels. Despite the benefits of treatment, which may also include anti-thrombotic and anti-diabetic effects and complete renal remission when given in combination with mycophenolate mofetil, the risks have been well documented. Most rheumatologists, optometrists, and ophthalmologists are aware of the risk for patients developing toxic retinopathy after hydroxychloroquine HCQ use. However, there remains considerable. May 16, 2011 Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists.