B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Chloroquine cutaneous lupus Plaquenil et exposition au soleil Plaquenil et alcool Mechanism of hydroxychloroquine Hydroxychloroquine Plaquenil is an older DMARD sometimes still used for mild RA. It may work by interrupting signaling among cells. It’s one of the best tolerated DMARDs. Side effects are usually mild and may include nausea and diarrhea. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2. Hydroquinone, also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C 6 H 4 OH 2. It has two hydroxyl groups bonded to a benzene ring in a para position. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Hydroquinone plaquenil Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Hydroxychloroquine Plaquenil - Can you drink alcohol while on hydroxychloroquineChloroquine retrovirus productionChloroquine iupac nameHigh triglycerides and plaquenilPlaquenil to treat lupus Although the relationship between exogenous ochronosis and the topical use of hydroquinone is well reported in literature, to the best of our knowledge, no cases have been reported on the development of ochronosis in association with the systemic use of hydroxychloroquine. A case of exogenous ochronosis associated with hydroxychloroquine. Hydroquinone - Wikipedia. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated. The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C 18 H 26 ClN 3 O. H 2 SO 4. Each hydroxychloroquine sulfate tablet intended for oral administration contains 200 mg of hydroxychloroquine sulfate equivalent to 155 mg base. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.