I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Is methotrexate the same as plaquenil Lupus medicine plaquenil Plaquenil, what to expect for the first time taking it. Skyllark • • 6 Replies. My wife will be taking Plaquenil for the first time, is there any things she should expect in taking it in starting to take the medication. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. What to expect when taking plaquenil for the first time Hydroxychloroquine MedlinePlus Drug Information, Plaquenil Side Effects Common, Severe, Long Term - Can plaquenil be taken with neurontinHow to taper off hydroxychloroquine I fully expect to be throwing up as I have to take 8 ml. Luckily I can take it with food apparently but there is no way that anything will be able to disguise that taste. I do manage to take my warfarin tablets with food and am now wondering whether plaquenil tablets are a similar size to warfarin or not, and if they can be taken with food. Plaquenil info please I have now. - Sticky Blood-Hugh.. Hydroxychloroquine Plaquenil. Taking Plaquenil for Rheumatoid Arthritis. Additional doses of 6.5 mg/kg maximum dose 400 mg should be given at the following times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Prevention The Plaquenil is supposed to kick in in 3 to 6 months. I think it was 8 months for me. One day I was congratulating myself for getting so many things done and I realised that the days had been getting better without my noticing. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said.