Synthesis of chloroquine from m chloroaniline

Discussion in 'Plaquenil Generic' started by dasha1974, 21-Feb-2020.

  1. Galina Gubinskaya Moderator

    Synthesis of chloroquine from m chloroaniline


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chemically, it is 7-chloro-4- 4- diethylamino-1-methylbutylaminoquinoline phosphate 12 andhas the following structural formula C 18 H 26 ClN 3.2H 3 PO 4 Molecular Weight 515.87 Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Can we get chloroquine from 4-amino-7-chloroquinoline 7-chloroquinolin-4-amine by adding 4-chloro-N,N-diethylpentan-1-amine $\ce{CH3CHClCH23NEt2}$ ? Stack Exchange Network Stack Exchange network consists of 175 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their. Chloroaniline 108-42-9 route of synthesis, 3-Chloroaniline chemical synthesis methods, 3-Chloroaniline synthetic routes ect. +86-400-6021-666 [email protected]

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Synthesis of chloroquine from m chloroaniline

    US2894035A - Preparation of m-chloroaniline - Google Patents, Synthesis of chloroquine from 4-amino-7-chloroquinoline

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  5. Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain Daniel P. Iwaniuk, 1 Eric D. Whetmore, 1 Nicholas Rosa, 1 Kekeli Ekoue-Kovi, 1 John Alumasa, 1 Angel C. de Dios, 1, 3 Paul D. Roepe, 1, 2, 3 and Christian Wolf 1, 3

    • Synthesis and antimalarial activity of new chloroquine..
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    • Chloroquine Phosphate - WebMD.

    The synthesis of formula I i.e. 4,7-dichloroquinoline from m-chloroaniline is well documented in the Prior art Org Synthesis, Collective Volume 3, 272. The preparation of intermediate of formula II 5-N-ethyl-N-2-hydroxyethyIamino-2-pentylamine is also reported in the prior art US 2546658. 5 Experimental Example 1 Aug 09, 2018 The synthesis will involve adding 2 substituents to the benzene ring. In this case, we'll need to consider the order of substitution. Cl is an ortho-para director. That means, if Cl is first added to benzene, the next substituent will be placed in the ortho/para position. That, will not work since, in the desired product, #NH_2# is meta to Cl. That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures. share improve this answer

     
  6. vidoss User

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