Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine tablets uses Plaquenil mefioquine Hydroxychloroquine is a CYP2D6 inhibitor, while cobicistat is a substrate of CYP2D6. Dasatinib Major Avoid coadministration of hydroxychloroquine and dasatinib. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. For treating lupus in adults, the recommended starting Plaquenil dosage is 400 mg once or twice a day. After a while, your healthcare provider may recommend a lower dosage such as 200 mg once daily. The higher the long-term dosage, the more likely that serious Plaquenil side effects especially eye damage may occur. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Usual doseagefor plaquenil Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Taking Plaquenil for Various Conditions and Treatment Tips Hydroxychloroquine prescribing information pdf The recommended Plaquenil dosage for malaria prevention is 400 mg once weekly, starting two weeks before the anticipated exposure. The usual starting dosage for treating lupus is 400 mg once or twice a day, and the recommended starting dose for the treatment of rheumatoid arthritis is 400 to 600 mg daily. Plaquenil Dosage - Antibiotics Home Page. Chloroquine Dosage Guide with Precautions -. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol.. Jun 30, 2015 The recommended dose of hydroxychloroquine Plaquenil for the treatment of malaria in adults is 800 mg followed by 400 mg in six to eight hours. This is followed by 400 mg on each of the next two days. The dosage for adults may also be calculated by body weight. Data from case series and retrospective and open-label studies support the use of hydroxychloroquine in the treatment of extensive cutaneous sarcoidosis Chong 2005, Jones 1990, Modi 2008. Contraindications. Known hypersensitivity to hydroxychloroquine, 4-aminoquinoline derivatives, or any component of the formulation. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.