Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Hydroxychloroquine and laser hair removal Hydroxychloroquine pka Buy aralen phosphate Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Drugs Recommended in Areas of Chloroquine-Sensitive Malaria Chloroquine Aralen For sensitive P. falciparum and P. vivax, chloroquine remains the drug of choice to prevent malaria. The standard doses are generally well tolerated and are safe for pregnant women and children. Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine sensitive malaria areas Chapter 8 - Drugs for the prevention and treatment of malaria., Malaria Travel & Health Guide, 2019 Online Book Chloroquine diphosphate side effectsAllergic reaction to hydroxychloroquine burn how longAmerican academy of ophthalmology plaquenil screening guidelinesIs there another drug like plaquenilIs there withdrawal from plaquenil An alternative to chloroquine for prophylaxis only in areas with chloroquine-sensitive malaria 310 mg base 400 mg salt orally, once/week 5 mg/kg base 6.5 mg/ kg salt orally, once/week, up to maximum adult dose of 310 mg base Begin 1–2 weeks before travel to malarious areas. Malaria Prevention –. Chloroquine - an overview ScienceDirect Topics. WHO Antimalarial drug efficacy maps. Nevertheless, it remains a drug of choice against sensitive P falciparum & other species of Plasmodium. As of 2015, the regions with chloroquine-sensitive malaria have been limited to parts of Central America, primarily in Hispaniola & west of the Panama Canal similar to that shown in Figure 2 for resistance patterns in 2010 Rosenthal, 2015. Prophylaxis of falciparum malaria in areas where resistance to chloroquine is moderate Child 1.7 mg chloroquine base/kg once daily always combined with proguanil Adult 100 mg chloroquine base once daily always combined with proguanil Travellers should start prophylaxis 24 hours before departure. Areas with chloroquine-sensitive malaria include many Latin American countries where there is predominantly P. vivax malaria. Chloroquine-sensitive P. falciparum is present in the Caribbean and Central American countries west of the Panama Canal. For destinations where chloroquine-sensitive malaria is present, in addition to mosquito avoidance measures, the many effective prophylaxis options include chloroquine, atovaquone-proguanil, doxycycline, mefloquine, and tafenoquine.