Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer. How does plaquenil help Claritin and plaquenil Chloroquine What to know about potential coronavirus treatment. Chloroquine, a drug in a multicountry clinical trial, has shown promise in becoming a potential treatment for COVID-19. Clinical trials are research studies that involve people. The clinical trials on this list are for colon cancer treatment. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Abstract. The PINC trial NCT01023477 examined the dosage efficacy of oral chloroquine CQ, an autophagy inhibitor, as a neoadjuvant therapy to reduce the volume, cause regression and decrease the recurrence of breast ductal carcinoma in situ DCIS, for any grade or ER/PR/Her2 status. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Chloroquine cancer clinical trials Treatment Clinical Trials for Prostate Cancer - National Cancer Institute, Treatment Clinical Trials for Colon Cancer - National Cancer Institute Optometry plaquenil dosage retinopathyOpthalmologic complication of hydroxychloroquineChloroquine lysosome acidificationOcular testing for plaquenil Is chloroquine a cure for coronavirus? Some scientists are touting the efficacy of the drug in preliminary studies, but are also noting that much more research needs to be done before confirming. Is Chloroquine a Cure for Coronavirus? Scientists Say.. Abstract CT140 PINC trial Preventing invasive. - Cancer Research. Study protocol of a phase IB/II clinical trial of metformin and.. Jun 22, 2018 These findings support clinical study of chloroquine to lower rates of venous thromboembolism in patients with cancer. Trial registration. This study reports correlative data from two clinical trials that registered with clinicaltrials.gov, NCT01128296 May 21, 2010 and NCT01978184 November 7, 2013. RESULTS Seven clinical trials were identified n = 293. Treatments included 2 combinations of hydroxychloroquine and gemcitabine, 1 combination of hydroxychloroquine and doxorubicin, 1 combination of chloroquine and radiation, 2 combinations of chloroquine, temozolomide, and radiation, and 1 hydroxychloroquine monotherapy. A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer CUBiC. The breast cancer tissue collected and stored during this clinical trial will offer a unique opportunity to study the effect of CQ on the biology of human breast tissue. RNA and gene expression levels will be extracted from participant.