Chloroquine resistance characteristics

Discussion in 'Reliable Pharmacy' started by Webster123, 16-Mar-2020.

  1. Arcky User

    Chloroquine resistance characteristics


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    Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms. Paloma F Salas, Christoph Herrmann, Jacqueline F Cawthray, Corinna Nimphius, Alexander Kenkel, Jessie Chen, Carmen de Kock, Peter J Smith, Brian O Patrick, Michael J Adam, Chris Orvig Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Nov 21, 2019 Drug Resistance. Resistance of Plasmodium falciparum to chloroquine is widespread and cases of Plasmodium vivax resistance have been reported. Indications and Usage for Aralen. Aralen is indicated for the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum.

    One of these ways consists of reacting 3-chloroaniline with ethoxymethylenmalonic ester to make (3-choroanilino)-methylenemalonic ester (37.1.1.4), which then undergoes high-temperature heterocyclization to make the ethyl ester of 7-chloro-4-hydroxyquinolin-3-carboxylic acid (37.1.1.5). In order to realize the synthesis, the necessary 4,7-dichloroquinoline (37.1.1.1) is prepared in several ways from 3-chloroaniline.

    Chloroquine resistance characteristics

    Chloroquine C18H26ClN3 - PubChem, Effects of chloroquine on viral infections an old drug.

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  4. This study registered a high chloroquine efficacy rate among the study participants. Therefore, chloroquine remains efficacious for the treatment of Plasmodium vivax malaria in the study area. However, there is a need to monitor chloroquine resistance by employing molecular tools for better evaluation of treatment outcome.

    • Therapeutic efficacy of chloroquine for treatment of..
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    • Characteristics and cross-resistance patterns of chloroquine..

    Chloroquine remains the treatment of choice for vivax malaria, except in Indonesia's Irian Jaya Western New Guinea region and the geographically contiguous Papua New Guinea, where chloroquine resistance is common up to 20% resistance. Chloroquine resistance is an increasing problem in other parts of the world, such as Korea and India. When chloroquine resistance is common or when chloroquine is contraindicated, then artesunate is the drug of choice, except in the U. S. where it is not. The resistance of Plasmodium vivax to chloroquine has become an obstacle to control strategies based on the use of anti-malarials. The current study investigated the association between P. vivax CQ-resistance in vivo with copy number variation and mutations in the promoter region in pvcrt-o and pvmdr1 genes. The study included patients with P. vivax that received supervised treatment with. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

     
  5. MexaHuk Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Drug resistance in malaria - World Health Organization Malaria Prophylaxis – Malaria Site Chloroquine-Resistant Malaria The Journal of Infectious.
     
  6. Nash4 Well-Known Member

    Hydroxychloroquine MotherToBaby In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. This sheet talks about whether exposure to hydroxychloroquine may increase the risk for birth defects over that background risk.

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  7. seoJin New Member

    Toxic Optic Neuropathy - EyeWiki Toxic optic neuropathy TON refers to visual impairment due to optic nerve damage caused by a toxin. Toxic optic neuropathy is characterized by bilateral, usually symmetric vision loss, papillomacular bundle damage, central or cecocentral scotoma, and reduced color vision.

    Medications that can Affect the Eye or Visual System