According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Hydroxychloroquine and sle Side effect of plaquenil on eyes Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Global Scenario of Drug Resistant Malariabr /P. falciparum resistancebr / Chloroquine resistant strains are found now in nearly all areas of chloroquine use including South America, Central America, east of the Panama Canal, the Western Pacific, East Asiabr /P. vivax resistancebr / Recent reports from Indonesia Irian Jaya. Although chloroquine-resistant P. falciparum was first reported near the India–Myanmar border in 1973, 4 chloroquine-resistant P. vivax was unknown in India until 1995, when two cases of infection with resistant P. vivax were detected in Mumbai. 5 In 1978, the National Malaria Eradication Programme now the National Vector Borne Disease. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Chloroquine resistance india Chloroquine with TB antibiotic may reduce drug resistance, MANAGEMENT OF CHLOROQUINE RESISTANT MALARIA BY Dr. HARMANJIT SINGH, D Plaquenil toxicity retinaDoes hydroxychloroquine suppress the immune systemHydroxychloroquine is it water pillPlaquenil breastfeedingPlaquenil bladder infection Two important currently used antimalarial drugs are derived from plants whose medicinal values had been noted for centuries artemisinin from the Qinghao plant Artemisia annua L, China, 4th century and quinine from the cinchona tree South America, 17th century.2 History of antimalarials Medicines for Malaria Venture. WHO Monitoring antimalarial drug resistance in India via sentinel.. Chloroquine resistant Plasmodium vivax malaria in India - Dua.. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine was being used in many areas during the study period. Earlier also, chloroquine resistance was shown by therapeutic efficacy studies, and India switched over to ACT for falciparum malaria all over the country 21. To conclude, the study showed high levels of resistance to chloroquine; and also to monodesethylamodiaquine. Chloroquine resistance occurs mostly in P.falciparum Pf, but P. vivax Pv responds to Chloroquine. The following policy has been adopted in India - 1 Uncomplicated P. vivax malaria.