Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine blindnesd Oct for plaquenil icd10 Low body fat and increase risk for chloroquine toxicity The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Small amounts of hydroxychloroquine can be found in breastmilk, but international experts indicate this medication is acceptable while breastfeeding. MECHANISM OF ACTION. Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Hydroxychloroquine mechanism of action Hydroxychloroquine Plaquenil Side Effects & Dosage for., Hydroxychloroquine Plaquenil RheumTutor Hydroxychloroquine sulfate tablets uspIs hydroxychloroquine a nsaid Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. Hydroxychloroquine Oral Route Precautions - Mayo Clinic. Hydroxychloroquine. Hydroxychloroquine Information for Providers AIDSinfo. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS. Hydroxychloroquine HCQ is nearly identical in structure to CQ and has a similar mechanism of action and therapeutic efficacy in rheumatological and infectious diseases. Like CQ, it also has a long half-life, and a very high volume of distribution. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown.