Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine sulfate 200 mg tablet Malaria drug hydroxychloroquine Hi Ides, I have found your question because, after taking Plaquenil for 2 weeks, I have extreme lower back pain. I checked out 'side effects of Plaquenil' on the Internet before contacting my Rheumy. On stopping the medication for 24 hours I had an improvement. How Does Plaquenil Work For Rheumatoid Arthritis. Hydroxychloroquine Plaquenil – American College of Rheumatology – It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works. How to use Plaquenil Hydroxychloroquine is usually taken with food. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil reduce pain Hydroxychloroquine Plaquenil Side Effects & Dosage for., How Does Plaquenil Work For Rheumatoid Arthritis Stop taking plaquenilChloroquine cancer It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. I've been. Plaquenil and pain" Rheumatoid Arthritis Community.. Plaquenil Oral Uses, Side Effects, Interactions.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications of RA. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.